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Dehydrogenative Cross‐Coupling of Primary and Secondary Alcohols
Author(s) -
Musa Sanaa,
Ackermann Lutz,
Gelman Dmitri
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300656
Subject(s) - dehydrogenation , chemistry , iridium , yield (engineering) , catalysis , aldol condensation , ligand (biochemistry) , primary (astronomy) , condensation , combinatorial chemistry , organic chemistry , coupling (piping) , coupling reaction , sequence (biology) , hydrogen , aldol reaction , photochemistry , metallurgy , biochemistry , materials science , receptor , physics , astronomy , thermodynamics
Abstract Homo‐ and cross‐coupling of alcohols resulting in the formation of the corresponding ketones in very good to excellent yield was realized through the one‐pot sequence of dehydrogenation/aldol condensation/hydrogenation accompanied by the release of molecular hydrogen. The dehydrogenation and hydrogenation steps are catalyzed by the previously reported ruthernium‐ and iridium‐based ligand‐metal cooperating catalysts.