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Generation of 4‐Cyanoisoquinolines and 4‐Amidylisoquinolines via a Palladium‐Catalyzed Cyanative Reaction of 2‐Alkynylbenzaldimines with Isocyanides
Author(s) -
Qiu Guanyinsheng,
Qiu Xiaochen,
Wu Jie
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300634
Subject(s) - chemistry , cyanation , palladium , isocyanide , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry
An efficient route to 4‐cyanoquinolines via a palladium‐catalyzed cyanative reaction of 2‐alkynylbenzaldimines with isocyanides has been developed. The transformation proceeds through 6‐ endo cyclization, isocyanide insertion, and cyanation. 4‐Amidylisoquinolines can be generated as well if water is involved in the reaction.