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Iron(III)‐Catalyzed Synthesis of 1,2,4‐Trisubstituted Imidazoles through the Reactions of Amidines and Aldehydes in Air
Author(s) -
Liu Xiang,
Wang Dong,
Chen Yongxin,
Tang Dong,
Chen Baohua
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300590
Subject(s) - chemistry , catalysis , environmentally friendly , reaction conditions , combinatorial chemistry , organic chemistry , ecology , biology
A novel and efficient iron(III)‐catalyzed synthesis of 1,2,4‐trisubstituted imidazoles through the reactions of amidines and aldehydes in air has been developed. Five hydrogen dissociations involving CH and NH bond activation are realized under mild conditions in this approach. The procedure is sustainable, simple and environmentally friendly.