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Palladium‐Catalyzed Desulfitative Direct CH Arylation of Electron‐Deficient Polyfluoroarenes with Sodium Arenesulfinates
Author(s) -
Miao Tao,
Wang Lei
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300587
Subject(s) - chemistry , palladium , reagent , catalysis , combinatorial chemistry , sulfinic acid , sodium , organic chemistry
The palladium‐catalyzed direct arylation of electron‐deficient polyfluorobenzenes was developed in the presence of silver carbonate and trisodium phosphate. This protocol allowed use of both electron‐deficient and electron‐rich aromatic sulfinic acid sodium salts as arylating reagents for the direct arylation of a variety of polyfluoroarenes to produce fluorobiaryls in good to excellent yields, providing a complement to the existing methods for the direct arylation of polyfluoroarenes.