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Atom‐Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst
Author(s) -
Shi Tao,
Guo Zhiwei,
Yu Huixian,
Xie Jianwu,
Zhong Yijun,
Zhu Weidong
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300554
Subject(s) - chemistry , enantioselective synthesis , metal organic framework , yield (engineering) , diamine , combinatorial chemistry , optically active , catalysis , organocatalysis , warfarin , ideal (ethics) , organic chemistry , medicine , philosophy , materials science , cardiology , epistemology , adsorption , atrial fibrillation , metallurgy
A novel chiral metal‐organic framework (MOF) organocatalyst has been developed, based on readily available MIL‐101 and the chiral primary diamine (1 R ,2 R )‐1,2‐diphenylethylenediamine, by the post‐synthetic modification. Over the developed chiral heterogeneous catalyst the asymmetric synthesis of ( S )‐warfarin with high enantioselectivity can be fulfilled on a gram‐scale (2.8 g) with excellent yield (92%) at low cost, making the synthesis method an ideal alternative to existing methods.