Phenyliodine Diacetate‐Mediated  para ‐Functionalizations of Amido‐ and Amino‐Substituted [2.2]Paracyclophanes | Zendy

Schaal née Lennartz Petra | Zendy; Baars Hannah | Zendy; Raabe Gerhard | Zendy; Atodiresei Iuliana | Zendy; Bolm Carsten | Zendy

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Phenyliodine Diacetate‐Mediated para ‐Functionalizations of Amido‐ and Amino‐Substituted [2.2]Paracyclophanes

Author(s) -

Schaal née Lennartz Petra,

Baars Hannah,

Raabe Gerhard,

Atodiresei Iuliana,

Bolm Carsten

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300547

Subject(s) - chemistry , nucleophile , hydrobromide , pyridine , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis

The reaction of N ‐[2.2]paracyclophanyl‐substituted amides or amines with phenyliodine diacetate (PIDA) and protic nucleophiles affords mixed para ‐substituted [2.2]paracyclophane derivatives in moderate to good yields. As protic nucleophiles carboxylic acids and alcohols as well as pyridine hydrobromide can be used. 4‐Hydroxy[2.2]paracyclophane reacts in an analogous manner.

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