Premium
Phenyliodine Diacetate‐Mediated para ‐Functionalizations of Amido‐ and Amino‐Substituted [2.2]Paracyclophanes
Author(s) -
Schaal née Lennartz Petra,
Baars Hannah,
Raabe Gerhard,
Atodiresei Iuliana,
Bolm Carsten
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300547
Subject(s) - chemistry , nucleophile , hydrobromide , pyridine , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis
The reaction of N ‐[2.2]paracyclophanyl‐substituted amides or amines with phenyliodine diacetate (PIDA) and protic nucleophiles affords mixed para ‐substituted [2.2]paracyclophane derivatives in moderate to good yields. As protic nucleophiles carboxylic acids and alcohols as well as pyridine hydrobromide can be used. 4‐Hydroxy[2.2]paracyclophane reacts in an analogous manner.