Premium
Gold(I)‐Catalyzed Functionalization of Benzhydryl C( sp 3 )H Bonds
Author(s) -
Cera Gianpiero,
Chiarucci Michel,
Dosi Federico,
Bandini Marco
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300525
Subject(s) - chemistry , surface modification , hydride , yield (engineering) , catalysis , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , metal , materials science , metallurgy
The selective activation/functionalization of benzhydryl C( sp 3 )H bonds is documented. The gold complex XPhosAuNTf 2 turned out to be an efficient catalyst (5 mol%) to transform readily available propargylic esters into di‐ or trisubstituted naphthalenes in high yield. A 1,5‐hydride shift is postulated as the key step of the cascade reaction sequence.