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Nickel‐Catalyzed Coupling of Fluoroarenes and Amines
Author(s) -
Zhu Feng,
Wang ZhongXia
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300485
Subject(s) - chemistry , nickel , catalysis , medicinal chemistry , hydrochloride , polymer chemistry , sodium , organic chemistry
The combination of bis(cyclooctadiene)nickel [Ni(COD) 2 ] and 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene hydrochloride (IPr⋅HCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert ‐butoxide ( t‐ BuONa). Activated, unactivated and deactivated fluoroarenes as well as fluoropyridines can react with cyclic or acyclic aliphatic amines. The reactions tolerate various functional groups in the fluorides including PhC(O), C(O)NEt 2 , CF 3 , OMe and vinyl groups.