Nickel‐Catalyzed Coupling of Fluoroarenes and Amines | Zendy

Zhu Feng | Zendy; Wang ZhongXia | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Nickel‐Catalyzed Coupling of Fluoroarenes and Amines

Author(s) -

Zhu Feng,

Wang ZhongXia

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300485

Subject(s) - chemistry , nickel , catalysis , medicinal chemistry , hydrochloride , polymer chemistry , sodium , organic chemistry

The combination of bis(cyclooctadiene)nickel [Ni(COD) 2 ] and 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene hydrochloride (IPr⋅HCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert ‐butoxide ( t‐ BuONa). Activated, unactivated and deactivated fluoroarenes as well as fluoropyridines can react with cyclic or acyclic aliphatic amines. The reactions tolerate various functional groups in the fluorides including PhC(O), C(O)NEt 2 , CF 3 , OMe and vinyl groups.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research