Organocatalyzed Synthesis of Isoxazolidin‐5‐ones: The Meldrum’s Acid Approach | Zendy

Postikova Svetlana | Zendy; Tite Tony | Zendy; Levacher Vincent | Zendy; Brière JeanFrançois | Zendy

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Organocatalyzed Synthesis of Isoxazolidin‐5‐ones: The Meldrum’s Acid Approach

Author(s) -

Postikova Svetlana,

Tite Tony,

Levacher Vincent,

Brière JeanFrançois

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201300465

Subject(s) - chemistry , ketene , domino , decarboxylation , meldrum's acid , nitrone , cycloaddition , organocatalysis , pericyclic reaction , base (topology) , organic chemistry , combinatorial chemistry , catalysis , enantioselective synthesis , mathematical analysis , mathematics

Meldrum’s acid has turned out to be a useful ketene equivalent when faced to nitrone dipoles to form various isoxazolidin‐5‐one derivatives under very mild Brønsted base organocatalytic conditions. The first asymmetric version of this original domino anionic formal [3+2] cycloaddition–decarboxylation reaction was demonstrated by means of quinine‐based organocatalysts.

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