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Copper(I) Iodide‐Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2‐ a ]pyridines from 2‐Aminopyridines and Methyl Ketones
Author(s) -
Chandra Mohan Darapaneni,
Reddy Donthiri Ramachandra,
Nageswara Rao Sadu,
Adimurthy Subbarayappa
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300456
Subject(s) - chemistry , aminopyridines , iodide , oxidative phosphorylation , oxygen , combinatorial chemistry , medicinal chemistry , methyl iodide , organic chemistry , biochemistry
We report here an operationally simple copper‐catalysed synthesis of imidazo[1,2‐ a ]pyridines through CH activation with oxidative linkage of two CN bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo[1,2‐ a ]pyridines including the antiulcer drug zolimidine from inexpensive and readily available 2‐aminopyridines and methyl ketones with broad range of functional group tolerance.