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Palladium‐Catalyzed Direct Alkoxycarbonylation of Aromatic CH Bonds via Selective CC Cleavage of α‐Keto Esters
Author(s) -
Zhou Wei,
Li Pinhua,
Zhang Yicheng,
Wang Lei
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300436
Subject(s) - chemistry , palladium , catalysis , cleavage (geology) , selectivity , pyrimidine , bond cleavage , medicinal chemistry , functional group , stereochemistry , organic chemistry , polymer , geotechnical engineering , fracture (geology) , engineering
A novel palladium‐catalyzed direct alkoxycarbonylation of 2‐arylpyridines, 2‐arylquinolines, benzo[ h ]quinolines, 2‐phenylpyrimidines, N ‐pyrimidine pyrroles and N ‐pyrimidine indoles via aromatic CH bond activation and selective CC cleavage of α‐keto esters has been developed. The method has the advantages of wide functional group tolerance, high selectivity, broad range of substrates and good yields.