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Phosphine‐Catalyzed [3+2] Annulation of Electron‐Deficient Alkynes with N ‐Hydroxyphthalimide: Synthesis of 3a‐Hydroxyisoxazolo[3,2‐ a ]isoindol‐8(3a H )‐ones
Author(s) -
Zhou QingFa,
Chu XuePing,
Ge FeiFei,
Wang Yue,
Lu Tao
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300426
Subject(s) - annulation , chemistry , phosphine , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry
The phosphine‐catalyzed [3+2] annulation of electron‐deficient alkynes with N ‐hydroxyphthalimide has been developed to give a variety of pharmaceutically attractive 3a‐hydroxyisoxazolo[3,2‐ a ]isoindol‐8(3a H )‐ones in good to excellent yields.