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Relay Redox and Lewis Acid Catalysis in the Titanocene‐ Catalyzed Multicomponent Assembly of 1,5‐Enynes
Author(s) -
Lepore Antonio J.,
Pinkerton David M.,
Ashfeld Brandon L.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300359
Subject(s) - chemistry , catalysis , aldehyde , relay , lewis acids and bases , redox , combinatorial chemistry , aryl , lewis acid catalysis , organic chemistry , power (physics) , physics , alkyl , quantum mechanics
Abstract Herein we describe a direct, multicomponent assembly of 1,5‐enynes. The titanocene‐catalyzed coupling of an aryl aldehyde, iodoalkyne, and allylsilane enables the convergent and rapid synthesis of this versatile architectural motif in good to excellent yields.