Premium
Chemo‐ and Enantioselective Brønsted Acid‐Catalyzed Reduction of α‐Imino Esters with Catecholborane
Author(s) -
Enders Dieter,
Rembiak Andreas,
Stöckel Bianca Anne
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300352
Subject(s) - chemistry , enantiopure drug , enantioselective synthesis , phosphoric acid , catalysis , brønsted–lowry acid–base theory , organic chemistry , combinatorial chemistry
The chemo‐ and enantioselective reduction of α‐imino esters with catecholborane has been developed employing 10 mol% of an enantiopure BINOL‐based phosphoric acid as organocatalyst. Various differently substituted aromatic α‐amino acid derivatives can be achieved in almost quantitative yields and very good to excellent enantioselectivities of up to 96% ee under mild reaction conditions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom