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Copper‐Catalyzed Synthesis of Imidazo[1,2‐ a ]pyridines through Tandem Imine Formation‐Oxidative Cyclization under Ambient Air: One‐Step Synthesis of Zolimidine on a Gram‐Scale
Author(s) -
Bagdi Avik Kumar,
Rahman Matiur,
Santra Sougata,
Majee Adinath,
Hajra Alakananda
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300298
Subject(s) - chemistry , imine , catalysis , tandem , combinatorial chemistry , amination , aryl , organic chemistry , oxidative phosphorylation , copper , materials science , alkyl , composite material , biochemistry
A new copper‐catalyzed oxidative cyclization via CH amination between 2‐aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2‐ a ]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one‐pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale.