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A Continuous Flow Solution to Achieving Efficient Aerobic Anti‐Markovnikov Wacker Oxidation
Author(s) -
Bourne S. L.,
Ley S. V.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300278
Subject(s) - markovnikov's rule , chemistry , wacker process , oxidation process , continuous flow , combinatorial chemistry , flow chemistry , process (computing) , organic chemistry , process engineering , biochemical engineering , catalysis , chemical engineering , palladium , computer science , regioselectivity , engineering , operating system
An aerobic anti‐Markovnikov Wacker oxidation for the flow‐synthesis of arylacetaldehydes is reported. In the process, flow chemistry techniques have provided a means to control and minimise the over‐oxidation of sensitive products. The reaction showed general applicability to various functionalised styrenes and provided a process capable of a multi‐gram scale.