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Triarylaminium Salt‐Initiated Aerobic Double Friedel–Crafts Reaction of Glycine Derivatives with Indoles
Author(s) -
Huo Congde,
Wang Cheng,
Sun Chougu,
Jia Xiaodong,
Wang Xicun,
Chang Wenju,
Wu Mingxia
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300276
Subject(s) - chemistry , friedel–crafts reaction , glycine , alkylation , salt (chemistry) , catalysis , oxygen , radical , organic chemistry , medicinal chemistry , amino acid , biochemistry
A novel and efficient stable radical cation triarylaminium salt‐catalyzed aerobic double Friedel–Crafts alkylation reaction of glycine derivatives with indoles has been developed. The reaction was performed in the absence of any other additives under mild conditions and only requires an air atmosphere (or oxygen, 1 atm) as co‐oxidant.