Premium
Synthesis of N ‐Arylamides by Copper‐Catalyzed Amination of Aryl Halides with Nitriles
Author(s) -
Xiang ShiKai,
Zhang DongXue,
Hu Hao,
Shi JiangLing,
Liao LiGuo,
Feng Chun,
Wang BiQin,
Zhao KeQing,
Hu Ping,
Yang Hua,
Yu WenHao
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300189
Subject(s) - chemistry , amination , benzoxazole , halide , aryl , nucleophile , catalysis , organic chemistry , copper , amide , combinatorial chemistry , alkyl
A copper‐catalyzed amination of aryl halides with nitriles has been developed. The use of nitriles as nitrogen nucleophiles can make the synthesis of N ‐arylamides more simple than that using amides through in‐situ hydrolysis. A variety of N ‐arylamides and benzoxazole derivatives can be synthesized according to this approach.