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Copper‐Catalyzed Aerobic Oxidative Carbocyclization– Ketonization Cascade: Selective Synthesis of Quinolinones
Author(s) -
Xie Peng,
Wang ZhiQiang,
Deng GuoBo,
Song RenJie,
Xia JiaDong,
Hu Ming,
Li JinHeng
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300160
Subject(s) - chemistry , catalysis , molecular oxygen , copper , oxygen , oxidative phosphorylation , organic chemistry , photochemistry , combinatorial chemistry , biochemistry
A new thematic extension method is described for the carbocyclization of α‐C( sp 3 )H bonds of amides with alkynes followed by ketonization of the alkynes that utilizes the inexpensive copper(II) acetoacetonate [Cu(acac) 2 ] as catalyst under an oxygen atmosphere to synthesize quinolinones. It is noteworthy that the oxygen atom of the newly formed carbonyl group is from atmospheric molecular oxygen.