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Direct C‐2 Alkylation of Quinoline N ‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction
Author(s) -
Wu Zhiyong,
Pi Chao,
Cui Xiuling,
Bai Jie,
Wu Yangjie
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300111
Subject(s) - quinoline , chemistry , palladium , catalysis , alkylation , molecule , coupling reaction , combinatorial chemistry , organic chemistry , photochemistry
An efficient and concise one‐pot strategy for the direct alkylation of quinoline N‐ oxides via palladium‐catalyzed dual CH bonds activation has been developed. This methodology provides quinoline‐containing heterocyclic molecules in moderate to excellent yields.