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A Desymmetrization Approach to the Enantiopure syn/anti ‐1,5‐Diols via Hydrolytic Kinetic Resolution (HKR) of Functionalized meso ‐Bis‐Epoxides: Further Elaboration to syn / syn ‐1,3,5‐Triols and Application to the Formal Synthesis of Cryptocarya Diacetate
Author(s) -
Kumar Pradeep,
Chowdhury Partha Sarathi,
Pandey Menaka
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300098
Subject(s) - enantiopure drug , desymmetrization , kinetic resolution , chemistry , hydrolysis , stereochemistry , organic chemistry , enantioselective synthesis , catalysis
A new approach has been developed for the synthesis of enantiopure syn / anti ‐1,5‐diols by desymmetrization of functionalized meso ‐bis‐epoxides using hydrolytic kinetic resolution (HKR). The usage of this protocol was demonstrated by converting syn ‐1,5‐diols into syn / syn ‐1,3,5‐triols and its subseqent application to the formal synthesis of cryptocarya diacetate.