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Palladium‐Catalyzed Decarboxylative Coupling of α‐ Oxocarboxylic Acids with C( sp 2 )H of 2‐Aryloxypyridines
Author(s) -
Yao Jinzhong,
Feng Ruokun,
Wu Zaihong,
Liu Zhanxiang,
Zhang Yuhong
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300078
Subject(s) - chemistry , palladium , acylation , catalysis , pyridine , decarboxylation , organic chemistry , medicinal chemistry
An efficient palladium‐catalyzed decarboxylative ortho ‐acylation of 2‐aryloxypyridines with α‐oxocarboxylic acids is described. In this new transformation, the aromatic C( sp 2 )H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2‐hydroxy aromatic ketones.