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Palladium(II)‐Catalyzed Efficient C‐3 Functionalization of Indoles with Benzylic and Allylic Alcohols under Co‐Catalyst, Acid, Base, Additive and External Ligand‐Free Conditions
Author(s) -
Das Debjit,
Roy Sujit
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300048
Subject(s) - chemistry , palladium , allylic rearrangement , catalysis , regioselectivity , ligand (biochemistry) , acetonitrile , medicinal chemistry , organic chemistry , base (topology) , tsuji–trost reaction , chloride , combinatorial chemistry , alkylation , mathematical analysis , biochemistry , receptor , mathematics
The bis(acetonitrile)palladium(II) chloride complex, PdCl 2 (MeCN) 2 , efficiently catalyzes the regioselective alkylation of indoles with various benzylic and allylic alcohols under moisture and air insensitive conditions. Notably the reaction does not require any other co‐catalyst, acid, base, additive, or external ligand.