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Double Gold‐Catalysed Annulation of Indoles by Enynones
Author(s) -
Heffernan Stephen J.,
Tellam James P.,
Queru Marine E.,
Silvanus Andrew C.,
Benito David,
Mahon Mary F.,
Hennessy Alan J.,
Andrews Benjamin I.,
Carbery David R.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201300018
Subject(s) - chemistry , annulation , alkyne , catalysis , combinatorial chemistry , tricyclic , organic chemistry , stereochemistry
The gold‐catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate‐catalysed process involving a mixture of CH activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6,5,7]‐tricyclic indoles are realised.