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Catalytic Enantioselective Addition of Alkyl Grignard Reagents to Aliphatic Aldehydes
Author(s) -
FernándezMateos Emilio,
Maciá Beatriz,
Yus Miguel
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201201117
Subject(s) - chemistry , enantioselective synthesis , reagent , catalysis , alkyl , organic chemistry , bromide , grignard reagent , combinatorial chemistry
Herein, we report an efficient catalytic system for the enantioselective addition of alkyl Grignard reagents to a broad range of aliphatic aldehydes with good yields and enantioselectivities. Remarkably, the challenging methylmagnesium bromide (MeMgBr) can also be added to a variety of aliphatic aldehydes, providing versatile chiral methyl carbinol units with unprecedented yields and enantioselectivities in a simple one‐pot procedure under mild conditions.