Iron(III)‐Catalyzed Cascade Reaction between Nitroolefins and 2‐Aminopyridines: Synthesis of Imidazo[1,2‐ a ]pyridines and Easy Access towards Zolimidine | Zendy

Santra Sougata | Zendy; Bagdi Avik Kumar | Zendy; Majee Adinath | Zendy; Hajra Alakananda | Zendy

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Iron(III)‐Catalyzed Cascade Reaction between Nitroolefins and 2‐Aminopyridines: Synthesis of Imidazo[1,2‐ a ]pyridines and Easy Access towards Zolimidine

Author(s) -

Santra Sougata,

Bagdi Avik Kumar,

Majee Adinath,

Hajra Alakananda

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201201112

Subject(s) - aminopyridines , chemistry , catalysis , cascade reaction , cascade , intramolecular force , combinatorial chemistry , organic chemistry , medicinal chemistry , chromatography

The iron(III)‐catalyzed one‐pot cascade reaction between nitroolefins and 2‐aminopyridines has been demonstrated for the synthesis of imidazo[1,2‐ a ]pyridines by exploiting the bielectrophilic nature of nitroolefins. This methodology could be successfully applicable for the synthesis of zolimidine, a useful drug for the treatment of peptic ulcer. The reaction proceeds through Michael addition followed by intramolecular cyclization and in situ denitration.

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