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Copper(I)‐Catalyzed Coupling Cyclization of Methyl Perfluoroalk‐2‐ynoates with 2‐Aminobenzonitriles: Synthesis of 2‐Perfluoroalkylated Quinolines
Author(s) -
Han Jing,
Cao Long,
Bian Linglin,
Chen Jie,
Deng Hongmei,
Shao Min,
Jin Zhijun,
Zhang Hui,
Cao Weiguo
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201201107
Subject(s) - chemistry , quinoline , catalysis , copper , coupling (piping) , medicinal chemistry , combinatorial chemistry , organic chemistry , mechanical engineering , engineering
An efficient route to 2‐perfluoroalkylated quinoline derivatives through the copper(I)‐mediated coupling–cyclization of 2‐aminobenzonitriles with methyl perfluoroalk‐2‐ynoates is described. Moderate to excellent yields have been achieved under mild conditions. The reaction mechanism is also discussed.