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One‐Pot Synthesis of Allylamine Derivatives by Iodine‐ Catalyzed Three‐Component Reaction of N‐Heterocycles, Paraformaldehyde and Styrenes
Author(s) -
Quan ZhengJun,
Hu WangHua,
Zhang Zhang,
Da YuXia,
Jia XiaoDong,
Wang XiCun
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201201097
Subject(s) - paraformaldehyde , chemistry , allylamine , catalysis , amide , organic chemistry , iodine , michael reaction , component (thermodynamics) , polymer chemistry , polyelectrolyte , polymer , physics , thermodynamics
The molecular iodine‐catalyzed three‐component reaction of amides or amide derivatives, paraformaldehyde and styrenes allows for the clean generation of allylamine derivatives in good yields and high regioselectivities. The reaction, forming water as the sole co‐product, is an experimentally easy to conduct transformation in the absence of transition metals under mild conditions.