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Copper‐Catalyzed Decarboxylation of Aromatic Carboxylic Acids: En Route to Milder Reaction Conditions
Author(s) -
Cahiez Gérard,
Moyeux Alban,
Gager Olivier,
Poizat Maël
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201201018
Subject(s) - chemistry , decarboxylation , catalysis , tetramethylethylenediamine , quinoline , copper , organic chemistry , reaction conditions , medicinal chemistry , polymer chemistry
The copper‐catalyzed decarboxylation of carboxylic aromatic acids has been advantageously achieved by using aliphatic amines like tetramethylethylenediamine (TMEDA) or hexamethylenetetraamine (HMTA) as ligands instead of the aromatic heterocyclic amines (quinoline, phenanthroline) used until now. The improvement is significant since the reaction can be performed at a lower temperature ( ca. 50 °C less) and the reaction time is clearly shorter (15 min instead of 12 to 24 h).