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Ligandless Copper‐Catalyzed Coupling of Heteroaryl Bromides with Gaseous Ammonia
Author(s) -
Fantasia Serena,
Windisch Johannes,
Scalone Michelangelo
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201201010
Subject(s) - chemistry , copper , catalysis , ammonia , coupling (piping) , in situ , combinatorial chemistry , inorganic chemistry , organic chemistry , mechanical engineering , engineering
Abstract A range of different N‐ and S‐containing heterocyclic bromides can be efficiently coupled with gaseous ammonia in the presence of copper(II) acetylacetonate [Cu(acac) 2 ] as catalyst and in the absence of additional ligands. Unstable aminothiophenes and aminobenzothiophenes can be further reacted in situ to afford functionalized derivatives.