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Palladium‐Catalyzed Direct Denitrogenative C‐3‐Arylation of 1 H ‐Indoles with Arylhydrazines using Air as the Oxidant
Author(s) -
Chen Yongxin,
Guo Shuaibo,
Li Kangning,
Qu Jinpeng,
Yuan Hua,
Hua Qiuru,
Chen Baohua
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200997
Subject(s) - chemistry , palladium , aryl , catalysis , reagent , combinatorial chemistry , bond cleavage , cleavage (geology) , organic chemistry , alkyl , geotechnical engineering , fracture (geology) , engineering
A novel palladium‐catalyzed approach to direct C‐3‐arylation of 1 H ‐indoles with arylhydrazines using air as the oxidant via CN bond cleavage has been developed. Various substituents are tolerated in this system in moderate to good yields. This reaction could also be compatible with a larger scale. Thus, this strategy using arylhydrazines as arylating reagents provides a powerful method for constructing substituted 3‐aryl‐1 H ‐indoles.