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Mild Palladium‐Catalyzed Oxidative Direct ortho‐ CH Acylation of Anilides under Aqueous Conditions
Author(s) -
Szabó Fruzsina,
Daru János,
Simkó Dániel,
Nagy Tibor Zs.,
Stirling András,
Novák Zoltán
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200948
Subject(s) - chemistry , benzophenone , palladium , acylation , catalysis , aqueous solution , yield (engineering) , oxidative phosphorylation , organic chemistry , quantum yield , combinatorial chemistry , biochemistry , materials science , metallurgy , physics , quantum mechanics , fluorescence
Palladium‐catalyzed cross‐dehydrogenative coupling between anilides and aromatic aldehydes was achieved under aqueous conditions. A wide variety of the desired benzophenone derivatives was isolated in good to excellent yield. The reaction rate acceleration effect of acid and detergent has been demonstrated. Mechanistic insight has been obtained from quantum chemical calculations.