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Palladium‐Catalyzed Oxidative Acylation of N ‐Benzyltriflamides with Aldehydes via CH Bond Activation
Author(s) -
Sharma Satyasheel,
Park Jihye,
Park Eonjeong,
Kim Aejin,
Kim Minyoung,
Kwak Jong Hwan,
Jung Young Hoon,
Kim In Su
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200889
Subject(s) - chemistry , acylation , regioselectivity , palladium , catalysis , acetic acid , oxidative phosphorylation , aryl , alkyl , medicinal chemistry , organic chemistry , biochemistry
A palladium‐catalyzed ortho ‐acylation of N ‐benzyltriflamides with aldehydes via direct sp 2 CH bond activation is described. Benzylamines with a triflamide directing group in the presence of palladium acetate, acetic acid, and tert ‐butyl hydroperoxide as an oxidant can be effectively coupled with aryl and alkyl aldehydes to provide ortho ‐acyl‐ N ‐benzyltriflamides with a high regioselectivity.