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Organocatalytic Asymmetric Addition of Thiols to Trifluoromethylaldimine: An Efficient Approach to Chiral Trifluoromethylated N , S ‐Acetals
Author(s) -
Fang Xin,
Li QingHua,
Tao HaiYan,
Wang ChunJiang
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200845
Subject(s) - chemistry , bifunctional , organocatalysis , enantioselective synthesis , organic chemistry , combinatorial chemistry , catalysis
The first organocatalytic asymmetric addition of thiols to trifluoromethylaldimine for the construction of chiral trifluoromethylated N , S ‐acetals has been achieved in high yields (up to 99%) and excellent enantioselectivities (up to 95% ee ) with 1 mol% of a bifunctional organocatalyst.
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