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Aerobic Dehydrogenative Heck Reactions of Heterocycles with Styrenes: A Negative Effect of Metallic Co‐Oxidants
Author(s) -
Vasseur Alexandre,
Harakat Dominique,
Muzart Jacques,
Le Bras Jean
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200787
Subject(s) - chemistry , catalysis , heck reaction , catalytic cycle , metal , photochemistry , mass spectrometry , electrospray ionization , palladium , organic chemistry , chromatography
The aerobic dehydrogenative Heck reaction (DHR) of heterocycles with styrenes was found to be more efficient in the absence of metallic co‐oxidants. According to a study of the isotope effect, the CH cleavage was the rate‐determining step of the catalytic cycle. Electrospray ionization mass spectrometry, subsequent MS/MS, and high‐resolution mass spectrometry were used to detect and characterize catalytic intermediates and species formed in the presence of metallic co‐oxidants.