Copper‐Catalyzed Tandem CC/CO Bond‐Forming Reactions of  ortho ‐Halo‐β‐chlorostyrenes with Ketones: Synthesis of 4‐Trifluoromethylbenzoxepines | Zendy

Sun LeiLei | Zendy; Hu BoLun | Zendy; Tang RiYuan | Zendy; Deng ChenLiang | Zendy; Zhang XingGuo | Zendy

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Copper‐Catalyzed Tandem CC/CO Bond‐Forming Reactions of ortho ‐Halo‐β‐chlorostyrenes with Ketones: Synthesis of 4‐Trifluoromethylbenzoxepines

Author(s) -

Sun LeiLei,

Hu BoLun,

Tang RiYuan,

Deng ChenLiang,

Zhang XingGuo

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200784

Subject(s) - chemistry , tandem , copper , catalysis , bromide , medicinal chemistry , trifluoromethyl , organic chemistry , alkyl , materials science , composite material

A copper‐catalyzed cyclization reaction of trifluoromethyl‐containing ortho ‐halo‐β‐chlorostyrenes with ketones has been developed. Using a combination of copper(I) bromide, 2,2,6,6‐tetramethylheptane‐3,5‐dione and sodium tert ‐butoxide, a variety of 4‐trifluoromethylbenzoxepines was prepared in moderate to good yields by the tandem α‐alkenylation of ketones with subsequent O ‐arylation.

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