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Copper‐Catalyzed Tandem CC/CO Bond‐Forming Reactions of ortho ‐Halo‐β‐chlorostyrenes with Ketones: Synthesis of 4‐Trifluoromethylbenzoxepines
Author(s) -
Sun LeiLei,
Hu BoLun,
Tang RiYuan,
Deng ChenLiang,
Zhang XingGuo
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200784
Subject(s) - chemistry , tandem , copper , catalysis , bromide , medicinal chemistry , trifluoromethyl , organic chemistry , alkyl , materials science , composite material
A copper‐catalyzed cyclization reaction of trifluoromethyl‐containing ortho ‐halo‐β‐chlorostyrenes with ketones has been developed. Using a combination of copper(I) bromide, 2,2,6,6‐tetramethylheptane‐3,5‐dione and sodium tert ‐butoxide, a variety of 4‐trifluoromethylbenzoxepines was prepared in moderate to good yields by the tandem α‐alkenylation of ketones with subsequent O ‐arylation.