Practical Enantioselective Hydrogenation of α‐Aryl‐ and α‐Carboxyamidoethylenes by Rhodium(I)‐{1,2‐Bis[( o ‐ tert ‐butoxyphenyl)(phenyl)phosphino]ethane} | Zendy

Mohar Barbara | Zendy; Stephan Michel | Zendy

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Practical Enantioselective Hydrogenation of α‐Aryl‐ and α‐Carboxyamidoethylenes by Rhodium(I)‐{1,2‐Bis[( o ‐ tert ‐butoxyphenyl)(phenyl)phosphino]ethane}

Author(s) -

Mohar Barbara,

Stephan Michel

Publication year - 2013

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201200780

Subject(s) - rhodium , chemistry , enantioselective synthesis , catalysis , aryl , medicinal chemistry , methanol , enantiomeric excess , enantiomer , hydrogen , organic chemistry , alkyl

The rhodium(I)‐{1,2‐bis[( o ‐ tert ‐butoxyphenyl)(phenyl)phosphino]ethane} [Rh(I)‐( t‐ Bu‐SMS‐Phos)] catalyst system displayed prime efficiency in the hydrogenation of large series of α‐amidostyrenes and α‐amidoacrylates. Up to >99.9% enantiomeric excesses coupled with very high reaction rates were attained operating routinely under 1–10 bar of hydrogen at 22 °C in methanol. Examples include industrial substrates.

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