Premium
Palladium‐Catalyzed CN Cross‐Coupling of N′ ‐Monosubstituted Sulfondiimines with Aryl Bromides
Author(s) -
Candy Mathieu,
Bohmann Rebekka Anna,
Bolm Carsten
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200754
Subject(s) - chemistry , palladium , aryl , catalysis , cleavage (geology) , medicinal chemistry , tris , combinatorial chemistry , organic chemistry , stereochemistry , biochemistry , alkyl , geotechnical engineering , fracture (geology) , engineering
A general method for the N‐arylation of sulfondiimines with aryl bromides using tris(dibenzylideneacetone)dipalladium(0) [Pd 2 (dba) 3 ] and 2‐dicyclohexylphosphino‐2′,6′‐diisopropoxybiphenyl (RuPhos) as catalyst system was developed. A new benzothiazine was obtained, and a protocol for the cleavage of para ‐methoxyphenyl (PMP) groups in PMP‐protected sulfondiimines has been found, which provides access to synthetically useful NH‐derivatives, that are difficult to prepare by other means.