Premium
Palladium‐Catalyzed Synthesis of Aromatic Ketones and Isoindolobenzimidazoles via Selective Aromatic CH Bond Acylation
Author(s) -
Lu Juyou,
Zhang Hao,
Chen Xiaowu,
Liu Hongxia,
Jiang Yuyang,
Fu Hua
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200743
Subject(s) - chemistry , trifluoroacetic anhydride , acylation , palladium , catalysis , organic chemistry , reagent , trifluoroacetic acid , organic synthesis , combinatorial chemistry
A convenient and efficient palladium‐catalyzed synthesis of aromatic ketones and isoindolobenzimidazoles has been developed via selective aromatic CH bond acylation. The protocol uses palladium acetate as the catalyst, readily available carboxylic acids as the acylating reagents, trifluoroacetic anhydride as the activated agent of the acids, and the corresponding aromatic ketones and isoindolobenzimidazoles were obtained in good to excellent yields. This finding should provide a new and useful strategy for synthesis of aromatic ketones and isoindolobenzimidazoles.