Premium
Highly Active Dinuclear Copper Catalysts for Homogeneous Azide–Alkyne Cycloadditions
Author(s) -
Berg Regina,
Straub Johannes,
Schreiner Ella,
Mader Steffen,
Rominger Frank,
Straub Bernd F.
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200734
Subject(s) - alkyne , cycloaddition , chemistry , azide , catalysis , copper , combinatorial chemistry , homogeneous catalysis , homogeneous , polymer chemistry , organic chemistry , physics , thermodynamics
The main feature of the herein presented class of molecularly defined catalysts for the copper‐catalyzed azide–alkyne cycloaddition reaction is the presence of two copper centres in one catalyst molecule. We report the facile three‐step synthesis of two representative bis‐NHC‐dicopper complexes as well as their catalytic performance in the azide–alkyne cycloaddition. A screening with one of these complexes has proved its wide applicability and excellent performance as homogeneous catalyst in various organic solvents and with different alkyne and azide substrates.