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N‐Heterocyclic Carbene‐Catalyzed Annulations of Enals and Ynals with Indolin‐3‐ones: Synthesis of 3,4‐Dihydropyrano[3,2‐ b ]indol‐2‐ones
Author(s) -
Lu Yingyan,
Tang Weifang,
Zhang Yu,
Du Ding,
Lu Tao
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200716
Subject(s) - chemistry , carbene , catalysis , organocatalysis , combinatorial chemistry , annulation , organic chemistry , enantioselective synthesis
Enal and ynal‐derived α,β‐unsaturated acylazoliums under N‐heterocyclic carbene (NHC) catalysis have been applied for annulations with indolin‐3‐ones. The two reactions offer a direct and efficient access to functionalized 3,4‐dihydropyrano[3,2‐ b ]indol‐2‐ones in moderate to high yields, which may provide promising candidates for drug discovery.