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Catalytic Stereoselective Conjugate Addition of Oxindole to Electron‐Deficient Alkynes
Author(s) -
Kang Guowei,
Wu Quanquan,
Liu Miaochang,
Xu Qingfang,
Chen Zunyang,
Chen Weilong,
Luo Yuqiang,
Ye Wei,
Jiang Jun,
Wu Huayue
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200715
Subject(s) - conjugate , chemistry , enantioselective synthesis , quinoline , stereoselectivity , oxindole , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics
A Z / E‐ selective and enantioselective conjugate addition of oxindoles to butyl but‐2‐ynedioate derivatives has been developed, providing a facile access to enantioenriched multifunctional olefins, which can be further converted into 3,3a‐ dihydro‐2 H ‐pyrrolo[3,4‐ c ]quinoline‐1,4(5 H ,9b H )‐dione derivatives via conventional operations.