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Cyanide as a Powerful Catalyst for Facile Preparation of 2‐Substituted Benzoxazoles via Aerobic Oxidation
Author(s) -
Cho Yeon Ho,
Lee ChunYoung,
Ha DeokChan,
Cheon CheolHong
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200684
Subject(s) - chemistry , cyanide , imine , catalysis , combinatorial chemistry , schiff base , organic chemistry , polymer chemistry
A cyanide‐catalyzed synthesis of 2‐substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one‐step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.