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Cross‐Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki–Miyaura Coupling in a Single Pass
Author(s) -
de M. Muñoz Juan,
Alcázar Jesús,
de la Hoz Antonio,
DíazOrtiz Angel
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200678
Subject(s) - chemistry , halide , catalysis , palladium , leaching (pedology) , reactivity (psychology) , coupling (piping) , coupling reaction , suzuki reaction , combinatorial chemistry , organic chemistry , metallurgy , medicine , materials science , environmental science , alternative medicine , pathology , soil science , soil water
A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura cross‐coupling in a single pass using a silica‐supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo‐halides and organoboron compounds can be used without modifying the standard procedure.