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Tunable Phosphine‐Mediated Domino Reaction: Selective Synthesis of 2,3‐Dihydrofurans and Biaryls
Author(s) -
Xie Peizhong,
Li Erqing,
Zheng Jie,
Li Xin,
Huang You,
Chen Ruyu
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200675
Subject(s) - chemistry , domino , synthon , phosphine , stoichiometry , combinatorial chemistry , catalysis , cascade reaction , product distribution , organic chemistry
We have developed a novel strategy to control the product distribution between 2,3‐dihydrofurans and biaryls from the same starting materials by tuning the catalytic or stoichiometric process. By controlling the loading of the phosphine PR 3 , the Morita–Baylis–Hillman carbonates can be selectively used as a C 1 or a C 3 synthon, respectively. This investigation has given new insights into tunable domino reactions and will be useful in diversity‐oriented synthesis (DOS).