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Iron‐Catalyzed Amidation of Aldehydes with N ‐Chloroamines
Author(s) -
Porcheddu Andrea,
Luca Lidia De
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200659
Subject(s) - chemistry , catalysis , reagent , substrate (aquarium) , scope (computer science) , chloride , iron(iii) chloride , organic chemistry , reaction conditions , combinatorial chemistry , oceanography , computer science , programming language , geology
A new direct conversion of aldehydes to amides has been realized, in the presence of iron(III) chloride as a catalyst and using tert ‐butyl hydroperoxide (TBHP) as an oxidant. Both aliphatic and aromatic aldehydes were successfully reacted with variously mono‐ and di‐substituted N ‐chloroamines. The methodology has a wide substrate scope, uses cheap and easily available reagents and is characterized by short reaction times.