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Direct Aza‐Darzens Aziridination of N ‐Tosylimines with 2‐Bromomalonates for the Synthesis of Highly Functionalized Donor‐Acceptor Aziridines
Author(s) -
Wu Xingxing,
Li Lei,
Zhang Junliang
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200628
Subject(s) - chemistry , sodium hydride , acceptor , scope (computer science) , combinatorial chemistry , hydride , organic chemistry , hydrogen , physics , computer science , programming language , condensed matter physics
An approach to highly functionalized donor‐acceptor aziridines by the aziridination of N ‐tosylimines and 2‐bromomalonates in the presence of sodium hydride under mild conditions has been developed. The high‐yielding reaction has a relatively broad scope and can be easily scaled up to the gram level.