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Iron‐Catalysed Reduction of Olefins using a Borohydride Reagent
Author(s) -
Carter Tom S.,
Guiet Léa,
Frank Dominik J.,
West James,
Thomas Stephen P.
Publication year - 2013
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200577
Subject(s) - chemistry , sodium borohydride , reagent , trifluoromethanesulfonate , sodium , reduction (mathematics) , medicinal chemistry , salt (chemistry) , borohydride , organic chemistry , catalysis , geometry , mathematics
The iron‐catalysed reduction of olefins has been achieved using a simple iron salt and sodium triethylborohydride. A wide range of mono‐ and trans ‐1,2‐disubstituted alkenes have been reduced (91–100%) using 25 mol% iron(II) triflate, 1 mol% N ‐methyl‐2‐pyrrolidinone and 4 equivalents of sodium triethylborohydride. The reduction of alkynes to alkanes is also reported (up to 84%). Significantly, the reduction of trisubstituted alkenes has also been achieved (60–86%).
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