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Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron‐Withdrawing Group‐Substituted Benzhydrols
Author(s) -
Ohshima Takashi,
Ipposhi Junji,
Nakahara Yasuhito,
Shibuya Ryozo,
Mashima Kazushi
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200536
Subject(s) - chemistry , trifluoromethanesulfonate , amination , allylic rearrangement , yield (engineering) , catalysis , polar effect , organic chemistry , medicinal chemistry , materials science , metallurgy
Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO 2 , or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf) 3 ] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further transformed into letrozole.