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Acceptorless and Base‐Free Dehydrogenation of Alcohols and Amines using Ruthenium‐Hydride Complexes
Author(s) -
Muthaiah Senthilkumar,
Hong Soon Hyeok
Publication year - 2012
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201200532
Subject(s) - dehydrogenation , chemistry , ruthenium , hydride , triphenylphosphine , catalysis , dissociation (chemistry) , hydrogen , organic chemistry , medicinal chemistry , combinatorial chemistry
An efficient, operatively simple, acceptorless, and base‐free dehydrogenation of secondary alcohols and nitrogen‐containing heterocyclic compounds was achieved by using readily available ruthenium hydride complexes as precatalysts. The complex RuH 2 (CO)(PPh 3 ) 3 ( 1 ) and Shvo’s complex ( 2 ) showed excellent activities for the dehydrogenation of secondary alcohols and nitrogen containing heterocycles. In addition to complexes 1 and 2 , the complex RuH 2 (PPh 3 ) 4 ( 3 ) also showed moderate to excellent activity for the acceptorless dehydrogenation of nitrogen‐containing heterocyclic compounds. Kinetic studies on the oxidation reaction of 1‐phenylethanol using complex 1 were carried out in the presence and the absence of external triphenylphosphine (PPh 3 ). External addition of PPh 3 had a negative influence on the rate of the reaction, which suggested that dissociation of PPh 3 occurred during the course of the reaction. Hydrogen was evolved from the oxidation reaction of 1‐phenylethanol by using 1 mol% of 1 (88%) and 2 (92%), which demonstrated the possible usage of the catalytic systems in hydrogen generation.